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Follicular hyperkeratinization (abnormally rapid shedding of skin cells) in the sebaceous gland and follicular infundibulum (uppermost section of the hair follicle, near the opening of the pores) can be considered one of the crucial events in the development of acne lesions. it is believed to be the second step in the pathogenesis of acne vulgaris. there are several terms for. Scenicview, you're theory seems to make some sense, but i wonder how is it any time i eat pizza or yellow cheese / other kinds of cheese i get breakouts instantly, but when i eat 2 servings of farmed salmon (not even wild), in servings of 150-200 gr and drinking 1 cup of goat milk kefir, (both containing alot of histamine) according to what google says.. no symptoms and no breakouts, i am so. Hi there,i suffer with lower back pain, been on accutane for almost 6 weeks now. acne acnelogy i run about 30kms a week and have had to cut down on the amount of running i normally do because of mainly sore hip joints....